Novel pH sensitive brush copolymers with biodegradable polyphosphoester side chains for use as nonviral gene vectors have been developed.
Prof. Mishra’s group at Banaras Hindu University, India has exhaustively studied two specific reactions of hydroxyl and perhydroxyl radicals.
The PEtOx-b-LPEI copolymer could have important applications in gene delivery and gene silencing as a polymeric vector.
Researchers at Iowa State University demonstrate the ability to simultaneously deliver proteins and DNA into plant cells.
A reducibly-degradable hyperbranched polymer PEI-SS-HP composed of LMW PEI via a disulfide-containing linkage is demonstrated as a promising gene vector.